Are pericytes considered as a type of vascular cells?

Pericytes are vascular cells that possess numerous functions and are situated within the capillary wall. They play a pivotal role in regulating cerebral blood flow (CBF), maintaining the blood-brain barrier (BBB), contributing to vascular development and stability, as well as neuroinflammation. Recently, the malfunctioning of pericytes in diseases like stroke and Alzheimer's disease (AD) has garnered significant attention.

What are the cells that pericytes are typically associated with?

Pericytes are versatile mural cells responsible for regulating crucial aspects of brain function, including angiogenesis, blood-brain barrier integrity, and vascular stability. In this study, the researchers delve into the abundance of brain pericytes and their potential correlation with vascular alterations observed in sporadic human arteriovenous malformations (AVMs).December 1st, 2018lung pericytes

Are pericytes classified as mesenchymal cells?

Pericytes are commonly regarded as mesenchymal stem cells (MSCs), which possess immense regenerative medicine potential as pluripotent progenitors residing within tissues. These cells, isolated from various tissues and cultured in vitro, have demonstrated the capacity to differentiate into numerous cell types, either in a controlled environment or after transplantation into a living organism.

What are the methods to recognize a pericyte?

Pericytes are distinguished not by a solitary identifier but rather through gene expression patterns that exhibit considerable variation among various organs. Pericytes play a pivotal role in orchestrating and preceding endothelial cell responses throughout the angiogenesis process.

What are the pericytes cells used for?

The contractile cells that support the renal microvasculature are called pericytes. These mesenchymal cells surround peritubular capillaries34 and, by their intimal relationship with endothelial cells, are essential for preserving the integrity of the microvasculature.

Are pericytes classified as mesenchymal cells?

It is commonly accepted that pericytes possess characteristics similar to mesenchymal stem cells (MSCs), serving as pluripotent progenitors residing in tissues, exhibiting immense regenerative medicine potential. When isolated from diverse tissues and cultured, pericytes demonstrate the ability to transform into numerous cell lineages in vitro, as well as following transplantation in vivo.a204 cell line

What are the consequences of not treating lung inflammation?

Undiagnosed or neglected pneumonitis has the potential to result in permanent harm to the lungs. Typically, the air sacs within healthy lungs exhibit a natural stretching and relaxing motion with each inhalation and exhalation. However, chronic irritation of the delicate tissue that coats each air sac can lead to scarring, ultimately rendering the sacs less resilient. Over time, they transform into a rigid state, resembling a desiccated sponge.

Does pluripotent have an advantage over multipotent?

Pluripotent cells possess the remarkable ability to transform into various cell types that constitute the entire body, and embryonic stem cells are classified as such. On the other hand, multipotent cells have the capacity to differentiate into multiple cell types, albeit with more constraints compared to pluripotent cells. Adult stem cells and cord blood stem cells are categorized as multipotent.huo9

What are the factors that trigger inflammatory reactions in the lungs?

The inflammatory response is intricate and encompasses numerous processes aimed at safeguarding against harmful agents and facilitating tissue restoration. In the lungs, inflammation often arises due to the presence of pathogens or as a result of exposure to toxins, pollutants, irritants, and allergens. As inflammation occurs, a diverse array of inflammatory cells become activated.

What are the identifying characteristics of pericytes?

Kcnj8, Abcc9, and Vtn (highlighted in yellow) serve as illustrative markers that are predominantly associated with pericytes, albeit their presence in veSMCs (denoted by green). Notably, canonical markers such as Anpep and Cd248 exhibit specificity for brain pericytes but fail to retain their predictive significance in the majority of other tissues, underscoring the existence of organ-specific specialization.